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Novavax vaccine – Development and deployment stages explained

Novavax vaccine – Development and deployment stages explained

Novavax’s COVID-19 vaccine is known by several names globally, including NVX-CoV2373 and Nuvaxovid in some regions. The vaccine uses a tiny piece of the SARS-CoV-2 virus’s spike protein as its primary antigen. This spike protein is the part of the virus that lets it enter human cells and enhance the body’s immune response. The vaccine further includes an adjuvant called Matrix-M. Here are a few details about the vaccine’s development and deployment. Preclinical development Novavax began developing the vaccine in early 2020 utilizing its nanoparticle technology platform. The company identified a stabilized SARS-CoV-2 spike protein as its antigen and combined it with an adjuvant (Matrix-M) to enhance the immune response. Phase 1 and phase 2 trials Novavax initially conducted clinical trials in two phases to evaluate the vaccine’s safety and immunogenicity. These trials involved a relatively small number of participants and aimed to determine the appropriate dosage. Phase 3 clinical trials In the latter half of 2020 and early 2021, Novavax initiated large-scale phase 3 clinical trials to assess the vaccine’s efficacy in preventing COVID-19. These trials involved thousands of participants in multiple countries. Authorization and approval The Novavax vaccine, like other COVID-19 vaccines, required regulatory authorization or approval by a country’s authorities before it could be used.

5 natural ways to delay a period

5 natural ways to delay a period

The inconvenience of having a menstrual period coincide with important events, vacations, or other life activities cannot be overstated. Some might choose to just deal with it, while others might want to look for natural ways to delay a period by a few days. Here are some natural ways that women have tried to delay their period; however, note that these methods have little scientific backing, so individual results may vary. Food Changes According to some anecdotes, the menstrual cycle can be influenced by food choices. Consuming foods rich in vitamin C, can help delay menstruation. Vitamin C increases the production of progesterone, a hormone that can delay the onset of menstruation. Citrus fruits, broccoli, and strawberries are all excellent sources of vitamin C, as is lime juice. Herbal Teas Certain herbal teas like chamomile and ginger could also help postpone menstruation. These teas can have a calming effect on the uterus. Drinking a cup or two daily a few days before the expected period may be effective in delaying it naturally. Gram lentils Although there are anecdotal claims that the consumption of lentils made from gram flour a few days before menstruation might delay its onset, it’s important to note that these reports lack scientific evidence.

Prurigo nodularis – 6 early signs and symptoms

Prurigo nodularis – 6 early signs and symptoms

Prurigo nodularis is a rare skin condition characterized by the development of itchy, raised, and often intensely scratched nodules on the skin’s surface. As per a report by Yale School of Medicine, this chronic condition affects approximately 72 per 1,00,000 people nationwide. It is important to detect the condition at an early stage to manage it better. This article lists the early signs of prurigo nodularis that should not be ignored: Understanding prurigo nodularis Prurigo nodularis primarily affects adults and typically starts with mild itching in a specific skin area. Over time, this persistent itch intensifies and evolves into a noticeable symptom. The following are some of the common and early signs to watch out for: 1. Itchy bumps and nodules One of the most common signs of prurigo nodularis is the development of small, raised, and hard bumps or nodules on the skin’s surface. These nodules are often scaly and can vary from a few millimeters to several centimeters. The intense itching compels individuals to scratch the affected areas, exacerbating the condition. 2. Persistent itching Prurigo nodularis can be irksome due to its unrelenting itch. This itching sensation can be so severe that it disrupts daily life activities and sleep patterns.

11 common signs of eosinophilic esophagitis

11 common signs of eosinophilic esophagitis

Eosinophilic esophagitis (EoE) is an inflammatory disorder affecting the esophagus, the muscular tube that connects the throat to the stomach. This condition is characterized by the accumulation of eosinophils, a type of white blood cell, in the esophageal tissue, which results in inflammation, scarring, and narrowing of the esophagus. Early diagnosis and timely intervention are important for effective management of EoE. This article discusses common signs and symptoms of EoE. Read on to learn more. Common signs of eosinophilic esophagitis Dysphagia (Difficulty swallowing) One of the hallmark signs of eosinophilic esophagitis is difficulty swallowing, a condition known as dysphagia. Individuals with EoE often experience the sensation that food is getting stuck in their throat or chest, making it challenging to swallow solid and liquid foods. This can lead to prolonged mealtimes and a fear of eating. Food impaction In severe cases, EoE can cause food impaction, which is when food gets stuck in the esophagus and requires medical intervention. Symptoms may include severe chest pain, difficulty swallowing, and a sensation of choking. Reflux symptoms EoE can mimic the symptoms of gastroesophageal reflux disease (GERD). Individuals may experience heartburn, regurgitation, and acid reflux. These symptoms may be particularly troublesome at night.

6 first-line treatments for atopic dermatitis in infants

6 first-line treatments for atopic dermatitis in infants

Eczema or atopic dermatitis is a skin condition that causes pain, itching, irritation, and inflammation. It can affect people of all ages, even infants. The first-line treatment for atopic dermatitis (eczema) in infants typically involves a combination of basic skincare and topical ointments. It’s essential to consult with a pediatrician or dermatologist for a personalized treatment plan before applying or considering any of the following options. Emollients (Moisturizers) One of the main problems of developing eczema is dry skin. So, keeping the skin well-hydrated is crucial. Dermatologists suggest applying a fragrance-free, hypoallergenic moisturizer or emollient to the affected areas at least twice daily and more often if needed. One should choose products that are specifically formulated for sensitive skin, as infants have soft skin that can easily develop a rash. Take care while bathing the infant Identify and avoid potential triggers, such as harsh soaps, that can exacerbate the condition. Dermatologists advise using lukewarm water for baths and suggest limiting the duration to 5-10 minutes maximum. Hot water is not advisable as it can dry out the child’s skin. Experts suggest using a mild, fragrance-free, hypoallergenic soap or cleanser for regular bathing. Also, later on, it’s important to gently pat the skin dry and not rub to prevent skin irritation.

Buying sportswear – Fashion tips and mistakes to avoid

Buying sportswear – Fashion tips and mistakes to avoid

When buying sportswear, it’s important to make stylish, functional, and comfortable choices for specific athletic activities. Simply going by the brand and buying because a favorite influencer or celebrity has promoted the products is a big mistake to avoid. Also, one must consider certain points specific to buying sportswear to ensure maximum benefit from the premium purchases. Here are some common fashion mistakes to avoid and tips to keep in mind while buying sportswear: Neglecting functionality Never prioritize style over functionality. Sportswear is designed to enhance overall performance and increase comfort while performing intense physical activities. While stylish sportswear is great, avoid sacrificing functionality for fashion. Some trendy styles may not provide the necessary support or comfort for a workout. Consider the type of sport or exercise and buy keeping these functionality points in mind before selecting brands. Ignoring fabric quality Avoid inferior-quality materials. Sportwear clothing should be able to endure a lot of physical strain during physical activity without the texture and fabric giving away. Consider buying sportswear made from durable, moisture-wicking, and breathable fabrics like polyester, spandex, or nylon. These materials help keep the covered areas dry and comfortable during workouts. Choosing a poor fit and not layering Avoid buying sportswear that is too tight or loose.

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11 Hacks to Leverage the Best Black Friday Deals

11 Hacks to Leverage the Best Black Friday Deals

With Black Friday 2023 approaching, buyers are gearing up to buy gadgets, home appliances, and other products that have probably been on their lists for long. Black Friday allows buyers to fulfill all their requirements at prices much lower than the market rates. Moreover, the shopping season offers a wide range of products from different categories, facilitating considerable variety. Here are some quick hacks and tips that can help one make the most of this sale season: Shop in the morning The best time to shop for deals during the shopping season is in the morning, as several retailers begin their days during the wee hours of the morning. Moreover, popular products typically run out of stock, especially if offered at highly reasonable prices. Thus, it is a good idea to begin one’s Black Friday shopping early on in the day to reap the benefits of the best deals. Check out the previous shopping season’s sales Another way to determine beforehand what products will likely go on sale is to check out the products offered on discount the previous shopping season. This analysis can help one earmark these products before the sale and buy them promptly as soon as Black Friday commences. Follow popular retailers on social media Today, all reputed brands are utilizing social media innovatively to advertise their products, increase brand recognition, and communicate with their target audiences and customers. Thus, most of the brands offering discounts on Black Friday are likely to inform their customers about the same in advance. Following one’s desired brands can help one effectively leverage the Black Friday and Cyber Monday offers by these companies. Subscribe to retail newsletters Retail newsletters provide considerable insight into upcoming sales and offers, helping one check out the products that are likely to be offered on sale during Black Friday.

50 Amazing Black Friday 2023 Deals to Expect

50 Amazing Black Friday 2023 Deals to Expect

The buzz surrounding Black Friday starts much before the actual day comes around. As it approaches, the offers on products and services keep getting more incredible. This is why buyers can expect amazing discounts on their favorite smartphones, jewelry, cars, mattresses, furniture, and many more items, even with Black Friday a few weeks away. Here are some of the offers that are expected in the grand build-up to Black Friday: Mattress deals Quality mattresses elevate one’s sleeping experience. Going by last year’s trends, shoppers can expect great discounts of up to $800 on mattresses during the pre-Black Friday and Black Friday phases. Many quality mattresses with such deals have features such as innerspring coils and gel memory foam for ultimate comfort. Smartphone deals Brand-new smartphones are almost always hot property, but that feeling gets further elevated during Black Friday. Although one cannot accurately predict the extent of discounts on smartphones, current trends suggest that shoppers can receive handsome price cuts of at least up to $270 on newly launched models. Such phones are expected to have powerful cameras and processors for highly efficient picture quality and overall performance, respectively. Apparel deals Shoppers can purchase their favorite designer wear, casual clothing, and sporty wear apparel with incredible discounts to the tune of about 60% off their original maximum retail prices. With these discounts, shoppers can purchase premium clothing items they’ve had on their wishlists for a while. Virtual Reality headset deals Gaming and several other applications become more immersive and awesome when one adds a VR headset to the mix. Based on current discount trends, retailers are likely to offer discounts of up to $160 on VR headsets. The headsets that come with such discounts have features such as about 64 GB to 256 GB RAM, ergonomically-placed controls to set the VR settings, and high processing speed for their visuals.